SC-8986

Santa Cruz Biotechnology, Inc. SANTA CRUZ HNF-1 (H-205): sc-8986 BIOTECHNOLOGY BACKGROUND HNF-1 (α and β), HNF-3 (α, β and γ), HNF-4 (α and γ), and HNF-6 compose, in part, a homoeprotein family designated the Hepatocyte Nuclear Factor family (1-4). The various HNF-1 isoforms regulate transcription of genes in the liver as well as in other tissues such as kidney, small intestine and thymus (1). HNF-3α, HNF-3β and HNF-3γ regulate the transcription of numerous hepatocyte genes in adult liver. HNF-3α and HNF-3β have also been shown to be involved in gastrulation events such as body axis formation (2,4). HNF-4 α and HNF-4 γ have been shown to be important for early embryo development. HNF-4a is expressed in liver, kidney, pancreas, small intestine, testis and colon; and HNF-4γ is expressed in each of these tissues except liver (3). HNF-6 has been shown to bind to the promoter of HNF-3 β , which indicates a potential role of HNF-6 in gut endoderm epithelial cell differentiation. Evidence suggests that HNF-6 may also be a transriptional activator for at least 22 other hepatocyte-enriched genes, including cytochrome P450 2C13 and α-1 antitrypsin (4). SOURCE HNF-1 (H-205) is a rabbit polyclonal antibody raised against a recombinant protein corresponding to amino acids 80-284 mapping within an internal region of HNF-1α of human origin. PRODUCT Each vial contains 200 µg IgG in 1.0 ml of PBS containing 0.1% sodium azide and 0.2% gelatin. Also available as HNF-1 (H-205) X TransCruz ant...