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SC-32750

Santa Cruz Biotechnology
Part Number SC-32750
Manufacturer Santa Cruz Biotechnology
Description CD223
Published Jul 16, 2009
Detailed Description SANTA CRUZ BIOTECHNOLOGY, INC. www.DataSheet4U.com CD223 (C9B7W): sc-32750 The Power to Question BACKGROUND CD223 (Lym...
Datasheet PDF File SC-32750 PDF File

SC-32750
SC-32750

Overview
SANTA CRUZ BIOTECHNOLOGY, INC.
www.
DataSheet4U.
com CD223 (C9B7W): sc-32750 The Power to Question BACKGROUND CD223 (Lymphocyte activation gene-3, LAG-3) is a high affinity MHC class II ligand present on the surface of CD4+/CD8+ T cells and NK cells.
CD223 shares homology in structure to CD4 molecules, having four similar extracellular Ig-like domains and structural motifs between D1-D3 and D2-D4 domains.
CD223 has a glutamic acid-proline (EP) repetitive sequence found in other functionally distinct mammalian, parasitic, and bacterial proteins that may influence a conserved biological function.
CD223+/CD4+/CD8+ T cells can associate with the T cell receptor (TCR) and downregulate TCR signaling in vitro.
CD223 inhibits CD4-dependent T cell function via its cytoplasmic domain .
CD223 Lys-468 within a conserved "KIEELE" motif is essential for interaction with downstream signaling molecules.
APPLICATIONS CD223 (C9B7W) is recommended for detection of CD223 of mouse origin by flow cytometry...


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